A transgenic animal contain in its own genome and gene introduction by one or the other technique of transfection. Transfection is the process or introducing the desired gene into the animal's. And the gene introduced by transfection is called transgene .
In animals transfection specifies the transfer of a DNA segment, either naked or by the use of vector, tranfer into the animal cell. This process is called transformation.
In case of animals, transformation has long been used to describe the change of normal cells that is non-tumourous cell, in culture to tumor like cells.
Objective of gene transfer
1- a majority of gene transfer aim at studies on promoter function, reporter gene expression, regulation of gene expression, functions of transferred genes or DNA sugences etc.
2- the transfer gene is coded on the bioinformatics tools such as gene bank, etc. For the help of coded the DNA segment to easy in the selection of gene.
3- genes have been transferred and expressed in culture cells line to obtain the proteins encoded by them. So that it can help us to modify the gene quantity for the cloning .
4- Genetic modification of animals may be aimed at improving their milk, meat, wool breed etc. For the commercial used.
5- Genes have been transferred into animals with view to obtain a large scale production of the proteins encoded by these gene in the product such as milk, urin or blood of such animals , these animals are often called bioreactor and the approach is referred to as molecular farmings or gene farmings
6- a special case of gene transfer aim to eliminate the symptoms and genetic diseases. In this case normal and functional copies of the defective gene are introduced into the patient or we can say host cell. This process is called Gene therapy
As we all know nowadays so many kind of trangene animals are present. The first animal transgenes by the used of milk products in huge numbers. Fisrt transgene cow named Rosie in 1997. Used for the huge production of milk. For this scientists introduce into this cow the human gene named human-alpha-lactobuliam . They used as a transgene animal her offspring is produced with this quality of milk . This gene only appear on female transgene cow.
Same as a sheep named dolly is transgene to produce more and more wool product . She have unlimited growth of hair in her body . She was introduced 6th July 1996. This is the another example of clone . But the real used of this animal is produced wool more then normal shepp.
Beside this the scientists used female horse and male donkey inbreeding to produce A mule. Which is infertile but they used for carry the weight. In mountain areas.
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